ACMN Editors's blog

Abstract

AIM:
The aim of this study was to test for the influence of ascorbic acid on tumorigenicity and metastases of implanted PAIII prostate cancer adenocarcinoma cells in syngeneic LW rats.

MATERIALS AND METHODS:
Hormone-refractory prostate cancer PAIII cells were implanted subcutaneously into immunologically intact, Lobund-Wistar (LW) rats. Intraperitoneal pharmacological doses of ascorbic acid were administered each day for the ensuing 30 days. On the 40th day, animals were sacrificed. Local tumor weights were measured, and metastases were counted.

Abstract

BACKGROUND:
Anecdotal information and case reports suggest that intravenously administered vitamin C is used by Complementary and Alternate Medicine (CAM) practitioners. The scale of such use in the U.S. and associated side effects are unknown.

METHODS AND FINDINGS:

A high dose of Vitamin C (as sodium ascorbate) kills mesothelioma cells in vitro.

When the cells were injected as a xenograft into mice, tumor growth was significantly decreased in mice receiving high dose sodium ascorbate compared to control mice (no vitamin C).

Abstract:

This paper by Dr John Wilson discusses the potential usefulness of using Vitamin C for the treatment of septic shock. As with most things serious, the earlier the treatment the better. The article is quite technical and complex, it is unfortunately for the reader a technical and complex problem.

If you are not familiar with this sort of research, or are struggling with some of the terms, we recommend that you read the Endotoxin and Vitamin C newsletter attached at the bottom of this column before you start on Dr Wilson's excellent paper.

Pretreatment with Ascorbic Acid Prevents Lethal Gastrointestinal Syndrome in Mice Receiving a Massive Amount of Radiation

Original study authors:
Yamamoto T, Kinoshita M, Shinomiya N, Hiroi S, Sugasawa H, Matsushita Y, Majima T, Saitoh D, Seki S.

Abstract:

Prevention Research Center, Yale University School of Medicine, Derby, CT 06418, USA.

OBJECTIVES:
Intravenous micronutrient therapy (IVMT), and specifically the Myers' Cocktail, is a popular approach for treating fibromyalgia syndrome (FMS) among
complementary and alternative medicine practitioners, but its efficacy is uncertain. This trial assessed the feasibility, safety, and provided insights into the efficacy of this therapy.

DESIGN:

Original study authors:
Clifford L.K.Pang1, 2, LU Daxiang1, QI Renbin1, ZHANG Tao2, WANG Zhen2, SUN Yong2
1 Department of Pathophysiology, Medical College of Jinan University, Guangzhou, 510632, China; 2 Guangdong Clifford Hospital, Guangzhou, 511495, China

Abstract:

Objective: To study the effect of high dose Vitamin C, administered intravenously, on treating implanted hepatoma in rats.

Robitaille et al found in a clinical study that even 100 gram intravenous doses of ascorbate do not push urinary oxalate excretion past 80mg in people with normal renal function...

The TACT trial, a $30,000,000 trial funded by the NIH in the USA has been running and actively recruiting since 2003. Recently allegations have been published in Medscape critical of the consent form given to patients, the safety of the trial and disclosure of interests by some of the investigators.

The original allegations are scathing and can be found here:
Atwood KC, Woeckner E, Baratz RS, Sampson WI. Why the NIH Trial to Assess Chelation Therapy (TACT)should be abandoned. Medscape J Med. 2008 May 13;10(5):115. PMID: 18596934

By David Stauth, OSU News and Communications Service

Source: Maret Traber, Ph.D., Linus Pauling Institute